"GH increases intracranial pressure, & makes you hyperglycemic"

Ellis Toussier etoussier at HOTMAIL.COM
Wed Jul 22 01:29:37 EST 1998

following: GH, Deprenyl, EDTA Chelation Therapy, etc.

>Robert Ames <gnome at istar.ca> wrote:
>>> GH increases BP and in particular increases intracranial pressure,
>>> which could be of concern to people prone to hemorrhagic strokes.
>>> And of course it makes you hyperglycemic.
>>Is this true?
>>Would you please back up these statements or point me someplace where 
>>can read more about this?

>You know, the tradition for scientific newsgroups is that you're
>supposed to do some minimal research before asking questions. The
>info on GH is in any standard reference, like the PDR for example.

>On the intracranial pressure, I've posted this before, so a Dejanews
>search would have found it, had you looked.

>From: amesr at interlog.net (Robert Ames)
>Date: 1996/07/23
>Message-ID: <pkH9xgxyYITD091yn at interlog.net>

>"The Food and Drug Administration, after receiving 6 reports of
>benign intracranial hypertension (pseudotumor cerebri) in patients
>treated with recombinant growth hormone, actively identified an
>additional 17 affected patients in the United States or abroad.
>Benign intracranial hypertension was also reported in three
>patients with resistance to growth hormone who were treated with
>insulin-like growth factor I, the primary mediator of the actions
>of growth hormone. ... Twenty-one patients had headaches or visual
>changes, and all 23 patients had papilledema when first examined"

>4. Malozowski S, Tanner LA, et al. 1993. Growth Hormone,
>Insulin-like Growth Factor I, and benign intracranial
>hypertension. NEJM. 329:665-666 (letter).

Mr. Ames, since this is such a serious side effect, I would like to know 
and hope you can tell us what was the dosage that these 23 affected 
patients in the United States and abroad were using?  

And so that we can calculate the probability of having this side effect, 
is there any idea of how many patients in the world were taking GH at 
that time?  

Also, since your post on DejaNews is dated July of 1996, and the report 
it refers to is from 1993, can you tell us what happened to these 23 
affected patients?  Did any go blind?  How many got better after their 
dosage was, I presume, reduced or suspended?

Also "of course it makes you hyperglycemic"... Dr. Ronald Klatz writes 
in chapter 9 of his book "Grow Young With HGH": Until quite recently, it 
appeared that a major drawback for the use of growth hormone was its 
effect on insulin.  It appeared to counter the effects of insulin on the 
metabolism of glucose, making people more insulin resistant.  For this 
reason, doctors excluded anyone who was diabetic or prediabetic from 
using the drug.  Rudman and others had found that some people had 
increased blood sugar, a sign of insulin resistance, and there was 
concern that long-term administration of growth hormone could make some 
people diabetic.  

In his earlier studies, Bengtson found that growth hormone treatment 
increased insulin resistance in patients after 6 weeks of treatment.  
But after six months of treatment, their insulin sensitivity returned to 
where it was before starting treatment.  "If you look at the large 
studies with growth hormone," he says, "there is no increased incidence 
of diabetes."  

Bengtson believes that the profound changes in body composition after 
six months may have counteracted its effect on insulin.  There is a 
close association between central obesity and insulin resistance.  By 
getting rid of abdominal fat, you can induce greater insulin 
sensitivity.  If insulin is more effective in disposing of glucose, then 
the glucose does not remain in the cells where it can cause 
protein-glucose complexes (AGE- Advanced Glycosolation Endproducts), a 
form of cellular garbage that accumulates with age and interferes with 
the workings of the cells.  While it is yet to be proven, it seems 
reasonable to assume that over the long run, stimulation of growth 
hormone by getting rid of abdominal fat could prevent type 2 diabetes or 
even reverse the disease process.  "Growth hormone promotes the action 
of insulin," says Hertoghe.  "When we use GH, it seems to direct the 
action of insulin towards putting sugar into the cardiac, muscle, and 
nerve cells, rather than into fat cells.  It seems that growth hormone 
may help diabetes."

Excuse me if I don't do research other than this before asking you these 
questions.  I am just a layman, and I don't even know what the "PDR" is, 
but I think even the PDR (Pediatric Desk Reference?) might be 

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