What=92s your opinion?
Recently we have discussed in our lab if growth factors like HB-EGF =
can be considered a protooncogenes.
To my opinion: =
when considering the definition of a protooncogene is a gene involved =
in proliferation and differentiation pathways, and when mutated it
causes in concert with other functionally related genes a cancer, then
HB-EGF could be also considered a protooncogene.