"Jan Coetzee" <coetzee_jv at peachnet.campus.mci.net> wrote:
>
>Could you give more information faulty recQ helicase?
>>Jan(John)
Hi,
When they sequenced the Werner syndrome gene they found it had a high
degree of homology to recQ helicases, such as E. coli recQ, c.elegans
F18C5C and yeast Sgs1. A mutated helicase could lower the expression of
gene products that various tissues would need high concentrations at
certain times. This would eventually cause all of the Werner symptoms
including graying hair, osteoporosis, artherosclerosis, cataracts,
diabetes, sarcomas etc.
Suggested reading: Epstein, C.J. et al (1996) Werner Syndrome: entering
the helicase era. Bioessays, Vol 18 no 12: 1025-1027.
Chuck
