Richard A. Lockshin (yo_doc at usa.pipeline.com) wrote:
: There have been attempts to create mice transgenic for familial
: Alzheimer's, but there was a bit of trouble with the reliability of what
: was reported. Some biotech companies claim to have good mice but are not
: circulating them or the data.
:: On Mar 13, 1996 16:04:42 in article <Re: Premature Ageing>,
: 'william at neuro.usc.edu (William Sun)' wrote:
::: >On a related topic, anyone know if there is an animal model (like mouse)
: >of Werner's Syndrome?
: >
: >
: >--
: >William Sun, Ph.D. Phone: (213)740-3406
: >University of Southern California FAX: (213)740-5687
: >Los Angeles, CA 90089-2520 http://rana.usc.edu:8376/~wisun/: >
: --
:: Richard A. Lockshin
To the best of my knowledge there is NO animal model of Werner's
syndrome in Humans. Such rodents would presumably only live for about 1
year. Perhaps such variants [?mutants] would be discarded by the animal
house staff. I do not know how to generate such animals.
Since the gene for Werner's syndrome in humans will be cloned, the
possibility will then exist to determine whether rodents have this gene,
and if they do, what they would be like if this gene was mutated or
deleted.
If anyone knows of or has heard talk of an animal model of Werner's
syndrome in humans, I would be extremely anxious and delighted to be
told about it; however, tenuous the information may be.
Sydney Shall
--
Sydney SHALL, Laboratory of Cell and Molecular Biology, Biology Building,
University of Sussex, Brighton, East Sussex BN1 9QG, ENGLAND.
Tel:+44.273.67.83.03 FAX:+44.273.67.84.33; E-Mail:Janet:S.Shall at uk.ac.sussex
Elsewhere:S.Shall at sussex.ac.uk EARN/BITNET:S.Shall%sussex at ukacrl
