I'm wondering if anyone could direct me toward proteins that might be
involved in recognition of single-stranded DNA breaks (SSB). The cell
line I'm working with has a decrease response to single-stranded DNA
damage, as evidenced by Western blottig, of p53. The p53 is wild-type,
and I'm curious as to whether the defect is in a regulatory region of p53
upstream somewhere, or whether the actual detection of single-stranded
breaks is faulty. Does anyone have knowledge as to what proteins are
specifically involved in detection SSBs?
I'd love to hear any discussion about other possible causes of this muted
p53 response. Thanks, in advance.
______________________________________________________________________________
|| Scott A. Selby 6098)o%:::%o(860
==== Univ. of Minnesota 098)o%:::%o(8609
| |__ Dept. of Med/Hematology 6o%:%o(86098)
| |-.\ Box 480 UMHC (86098)o
|__| \\ Minneapolis, MN 55455 6098)o%::%o9
|| || 098)o%::::::%o9
======__| selby at lenti.med.umn.edu 6o%::::::%o(860
________||__ 6o%::%o(8609
/____________\ o(86098)
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