Malatonin and ageing

Jo Robinson jor at TELEPORT.COM
Sat Nov 18 13:59:55 EST 1995

On Fri, 17 Nov 1995, Marek Tchorzewski wrote:

> Hi,
>  OK,  but what happen to melatonin after oxidation ?
> Marek
	Marek, to quote Reiter in his review of melatonin's
antioxidant properties:
	"Once melatonin gives up an electron to a free radical, it
becomes an indolyl cation radical.  Thereafter, the indoyl cation radical
is quickly oxidized by the omnipresent superoxide anion radical to form
5-methoxy-N-acetyl-N-formyl-kynuramine.  Thus melatonin is irreversibly
oxidized and cannot be regenerated as is the case with some other anti-
	["A review of the evidence supporting melatonin's role as
an antioxidnat." Reiter, R J. et al. J. Pineal Research 1995;
18:1-11.]  For those of you who want to get into this level of detail,
I highly recommend this article.


|       Jo Robinson		    |            jor at teleport.com             |
|      (503)284-4676                |     2826 NE 18th Portland, OR 97212     | 

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