On Fri, 17 Nov 1995, Marek Tchorzewski wrote:
>> Hi,
>> OK, but what happen to melatonin after oxidation ?
>> Marek
Marek, to quote Reiter in his review of melatonin's
antioxidant properties:
"Once melatonin gives up an electron to a free radical, it
becomes an indolyl cation radical. Thereafter, the indoyl cation radical
is quickly oxidized by the omnipresent superoxide anion radical to form
5-methoxy-N-acetyl-N-formyl-kynuramine. Thus melatonin is irreversibly
oxidized and cannot be regenerated as is the case with some other anti-
oxidants."
["A review of the evidence supporting melatonin's role as
an antioxidnat." Reiter, R J. et al. J. Pineal Research 1995;
18:1-11.] For those of you who want to get into this level of detail,
I highly recommend this article.
Jo
>
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