In responding to Dr. Peter Proctor <proctorp at delphi.com>,
Dr Jim Cummins <cummins at POSSUM.MURDOCH.EDU.AU> wrote:
>You wrote:
>>> Don't confuse the experimental difficulties and the limitations
>>of ( e.g., ) antioxidant supplimentation with evidence against
>>a role for free radiacals in aging. We may be looking at the wrong
>>thing. E.g., antioxidants may not work in mitochondrial radical-induced
aging.
>>>>After over 25 years of research in this area, I still get
>>suprised. Look at PBN-- It seems to derive its antiaging activity
>>from * production * of a free radical, nitric oxide ( according
>>to Cutlers group at NIH ).
>>>Do you have references for this, please? I agree with your point on the
>paradoxical effects of free radicals: in my own area for example (sperm
>function) H2O2 is highly toxic to sperm but at very low levels is now seen
>as a central messenger in the acrosome reaction-essential for
>fertilization. I can supply refs if people are interested (not really
>relevant to this list).
The paper you are refering to might be:
"Nitric oxide formation during light-induced decomposition of
phenyl N-tert-butylnitrone"
by CHAMULITRAT-W; JORDAN-S-J; MASON-R-P; SAITO-K; CUTLER-R-G
Lab. Mol. Biophysics, National Inst. Environmental Health Sci., NIH,
P.O. Box 12233, Research Triangle Park, NC 27709 USA
in JOURNAL OF BIOLOGICAL CHEMISTRY [1993] 268(16): 11520-11527
Regards,
Lou Pagnucco (lpagnucco at delphi.com)
