Oral Tolerance
"Oral tolerance is a long recognized method to induce peripheral
immune tolerance. The primary mechanisms by which orally
administered antigen induces tolerance are via the generation of
active suppression or clonal anergy. Low doses of orally
administered antigen favor active suppression whereas higher
doses favor clonal anergy. The regulatory cells that mediate active
suppression act via the secretion of suppressive cytokines such as
TGF beta and IL-4 after being triggered by the oral tolerogen.
Furthermore, antigen that stimulates the gut-associated lymphoid
tissue preferentially generates a Th2 type response. Because the
regulatory cells generated following oral tolerization are
triggered in an antigen-specific fashion but suppress in an antigen
nonspecific fashion, they mediate bystander suppression when
they encounter the fed autoantigen at the target organ. Thus it may
not be necessary to identify the target autoantigen to suppress an
organ-specific autoimmune disease via oral tolerance; it is
necessary only to administer orally a protein capable of inducing
regulatory cells that secrete suppressive cytokines. Orally
administered autoantigens suppress several experimental
autoimmune models in a disease- and antigen-specific fashion; the
diseases include experimental autoimmune encephalomyelitis
(EAE), uveitis, and myasthenia, collagen- and adjuvant-induced
arthritis, and diabetes in the NOD mouse. In addition, orally
administered alloantigen suppresses alloreactivity and prolongs
graft survival. Initial clinical trials of oral tolerance in multiple
sclerosis, rheumatoid arthritis, and uveitis have demonstrated
positive clinical effects with no apparent toxicity and decreases in
T cell autoreactivity." (55)
There is strong evidence that inflammatory processes are involved
with AD, via an autoimmune response. This is also the case in
rheumatoid arthritis. Antiinflammatory drugs which are used in
arthritis also may have efficacy in AD (51-53), indicating a
common cause or disease process. Oral tolerization has beneficial
effects on arthritis. Therefore, it seems logical to assume that it
might be effective against AD. There is evidence that brain tissue
of non-human origin is similar enough to human tissue to induce
AD patient antibody recognition: "Serum from AD patients
contained antibodies that recognized cholinergic neuronal elements
in the adult rat brain, namely the medial septum, hippocampus,
and cortex. Another group of investigators showed that AD serum
contained antibodies directed against the purely cholinergic
Torpedo electromotor neurons." (50) Consumption of healthy
animal brain tissue is not known to have adverse side effects . Oral
consumption of myelin has succeeded in reducing the frequency of
Multiple Sclerosis attacks. (56)
I therefore recommend daily or weekly consumption of small
amounts of healthy animal brain tissue by Alzheimer's patients.
Preparation should be directed toward leaving the tissue as intact
as possible.
Alzheimer's Disease Therapy
Recommendations- A Summary
I suggest 10 mg of deprenyl be taken daily (5 mg with breakfast,
5 mg with lunch) for any Alzheimer's patient.
I suggest the consumption of 2 grams of Acetyl-L-Carnitine daily
in divided doses with meals by AD patients.
I recommend the AD patient take three times daily with meals at
least 400 i.u. of vitamin E, one half gram of vitamin C, 25,000
i.u. of beta carotene (or, even better, consumption of a high dose
multivitamin) , and 200 mcg of selenium. Also take 120 mg
Coenzyme Q10, and 120 mg B-6 in three divided doses.
Additionally, the patient should try to maximize his/her
consumption of fruits and green vegetables, striving for five to six
servings a day.
I suggest consumption of a magnesium supplement sufficient to
provide 400-800 mg of elemental magnesium per day. Example: 2
tablets of magnesium chloride (OTC: Slo-Mag) three times a day
(6 total/day) with meals. This will provide about 400 mg of
elemental magnesium per day.
I suggest nightly consumption of 6 to 10 mg melatonin just before
going to sleep, and consumption of an additional 3 mg if the patient
wakes up in the night with at least 4 hours of sleep to go. When
timed-release melatonin becomes available, I suggest using that.
I suggest daily hormone replacement therapy with DHEA (one
capsule in the morning) to achieve youthful DHEA levels for
Alzheimer's patients.
I suggest pregnenolone supplementation of 30mg/day initially for
Alzheimer's patients. Typical dosages vary from 10-100mg/day.
I recommend daily or weekly consumption of small amounts of
healthy animal brain tissue by Alzheimer's patients. Preparation
should be directed toward leaving the tissue as intact as possible.
If no antiinflammatory drugs are currently being taken by the
Alzheimer's patient, I recommend one enteric-coated 325-mg
aspirin be taken with breakfast, and one ibuprofen tablet be taken
with dinner.
If the disease continues to progress with all of the above therapy
modalities, including aspirin and ibuprofen therapy, I recommend
initial therapy with indomethacin (100-150 mg/day). Due to
possible exacerbation of gastric problems, discontinue aspirin and
ibuprofen therapy during indomethacin use. If indomethacin
cannot be tolerated, then re-initiate aspirin and ibuprofin
therapy, and try chronic administration of prednisone at low doses
(10 mg/day or less). Commence a search for a nonsteroidal
antiinflammatory drug which can be tolerated.
References (Starred references [*] are included in
this package)
1* Development of pharmacological treatments for Alzheimer-
type dementia. (1994) J. Royal Soc. Med. 87:Supp. 23
2*. "Possible New Test Found for Alzheimer's Disease", Science:
Vol 266, 11 Nov 1994, pp. 973
3*. "A Potential Noninvasive Neurobiological Test for Alzheimer's
Disease", Science: Vol 266, 11 Nov 1994, pp. 1051-1053
4. Alternatives in the treatment of memory loss in patients with
Alzheimer's Disease, Clin Pharm 1991 Jun;10(6):447-56
5. Deprenyl-medication: a strategy to modulate the age-related
decline of the striatal dopaminergic system (1992) J Am Geriatr
Soc Aug;40(8):839-847
6*. The pharmacological basis of the beneficial effects of deprenyl
in Parkinson's and Alzheimer's diseases, J Neural Transm
(1993) [Suppl]40:69-91
7. Clinical issues of cognitive enhancers in Alzheimer disease
(1991) Alzheimer Dis Assoc Disord 5 Suppl 1:S25-31
8*. The Pharmacological Profile of Deprenyl and its Relevance for
Humans: A Personal View (1992) Pharmacology & Toxicology
70:317-321
9*. Physicians Desk Reference (1994) Eldepryl 2309-2311
10*. Long-term efficacy and safety of deprenyl (selegiline) in
advanced Parkinson's disease (1989) Neurology 39:1109-1111
11*. Combination of tacrine and selegiline in Alzheimer's disease:
An open pilot study. 4th Int'l Conference on Alzheimers, S136
12*. Rationale for the use of selegiline in the treatment of
Alzheimer's Disease. 4th Int'l Conference on Alzheimers, S66
13*. Acetyl-L-Carnitine: A Drug Able to Slow the Progress of
Alzheimer's Disease? (1993) Ann NY Acad Sci, Vol. 640:228-
232
14*. Acetyl-Carnitine and Alzheimer's Disease (1992) Nutrition
reviews, 50:5; 142-143.
15*. The role of oxidative abnormalities in the pathophysiology of
Alzheimer's disease (1991) Rev Neurol 147(6-7):513-25
[Abstract only included]
16*. Free radicals in brain metabolism and pathology (1993)
British Medical Bulletin 49:3;577-587
17*. Involvement of Free Oxygen Radicals in B-Amyloidosis: An
Hypothesis (1994) Neurobiology of Aging 15:4; 443-455
18*. Effects of dopaminergic drugs on superoxide dismutase:
implications for senescence (1993) J Neural Transm
[Suppl]40:37-45
19. Neurology (Febuary, 1994) Author: Dr. John Breitner, Duke
University
20* Discussion on tacrine (1994) Alzheimer Disease and
Associated Disorders Vol 8, Suppl 2, pp. S58
21*. Coenzyme Q10, iron, and vitamin B6 in genetically-
confirmed Alzheimer's Disease (1992) Lancet 340:671-672
22*. Magnesium Supplements (1994) Physicians Desk Reference
1793-1798
23*. Melatonin, hydroxyl radical-mediated oxidative damage, and
aging: A hypothesis (1993) J. Pineal Res 14:151-168
24. Melatonin in human cerebrospinal fluid: Its origin and
variation with age. Life Sci.(1979) 25:929-936
25*. Plasma melatonin rhythm in in normal aging and
Alzheimer's Disease (1986) J. Neural Transm. Suppl. 21:494
26. Alterations in nocturnal serum melatonin levels in humans
with growth and aging (1988) J. Clin. Endocrinol. Metab.
66:648-652
27. Daily variation in the concentration of melatonin and 5-
methoxytryptophol in the human pineal gland: Effect of age and
Alzheimer's Disease (1990) Brain Res. 628:170-174
28*. The pineal control of aging: The effects of melatonin and
pineal grafting on the survival of older mice (1991) Ann. N.Y.
Acad. Sci. 621:291-313
29. Pineal gland and aging (1991) Aging 3:103-116
30. The aging pineal gland and it's physiological consequences
(1992) Bioessays 14:169-175
31. Concentrations of serotonin and its related substances in the
cerebrospinal fluid in patients with Alzheimer's type dementia
(1992) Neurosci. Lett. 141:9-12
32*. Pituitary-adrenocortical and pineal activities in the aged rat
(1991) Ann. N.Y. Acad. Sci. 621:256-261
33. Antioxidant capacity of melatonin: A novel action not requiring
a receptor (1993) Neuroendocrinol. Lett. 15:103-116
34*. Melatonin and sleep in humans (1993) J Pineal Res 15:1-
12
35. Barrett-Connor, E., K.T. Shaw, S.S.C. Chen (1986) New
England J Med 315:1519
36*. Antiglucocorticoid Effects of DHEA-S in Alzheimer's Disease
(1992) Am J Psychiatry 149:8, 1125-1126
37. Cognitive effects of corticosteroids (1990) Am J Psychiatry
147:1297-1303
38. DHEA-S serum levels in normal aging and Alzheimer's Disease
(1991) Age 14:116-118.
39*. Letter, reply to ref. 36, (1992) Am J Psychiatry 149:8,
1126
40*. DHEA Gets Respect (1994) Harvard Health Letter, July
1994 1-3
41*. Reduced plasma DHEA concentrations in Alzheimer's Disease
(1989) Lancet ii:570
42*. DHEA- the mother steroid: Part I. Immunologic Action
(1994) Annals NY Acad Sci. 719:553-563
43*. Hormonal intervention: "buffer hormones" or "state
dependency." The role of DHEA, thyroid hormone, estrogen and
pypophysectomy in aging. Annals NY Acad Sci. 521:260-273
44*. DHEA-S in the Oldest Old, Aged 85 and Older (1994) Ann NY
Acad Sci 719:543-552
45*. The Endocrinology of Aging: Can we prevent senescence?
(1994) Extro 1, pp. 101-128
46. Effects of adrenal androgens on the transplantable human
prostate tumor, Endocrinology 131:2909-2913
47*. Memory-enhancing effects in male mice of pregnenolone and
steroids metabolically derived from it (1992) Proc Natl Acad Sci
USA Mar 1;89(5):1567-71
48*. Inflammatory Mechanisms in Alzheimer's Disease (1994)
Am J Psychiatry 151:8;1105-1113
49*. 45th Forum in Immunology: Immunological factors in
Alzheimer's Disease: Implications for therapy (1992) Res.
Immunol. 143:675-683
50*. Cerebrospinal fluid antibodies: an indicator for immune
responses in Alzheimer's disease (1992) Res Immunol.
143:663-667
51*. Neuroimmune Mechanisms in Alzheimer disease
Pathogenesis (1994) Alzheimer Disease and Associated Disorders
8:3;149-158
52*. New Alzheimer's Therapy Suggested (1993) Science:260;18
Jun, pp. 1719-1720
53*. Clinical trial of indomethacin in Alzheimer's disease (1993)
Neurology Aug;43(8):1609-11
54*. Indomethacin and Indocin (1994) Physicians Desk
Reference, 1472-1473
55*. Oral tolerance: Immunologic mechanisms and treatment of
animal and human organ-specific autoimmune diseases by oral
administration of autoantigens (1994) Annu Rev
Immunol.12:809-37
56*. Double-Blind Pilot Trial of Oral Tolerization with Myelin
Antigens in Multiple Sclerosis (1993) Science 259:1321-1324
Alzheimer's Disease- Recommended Action Checklist
Make an appointment with an opthalmologist and have the
eye test performed.
If the results are positive, make an appointment with your
physician. Bring the results of the patients eye test and this
package Attempt to get his/her cooperation in your program. If
you have health insurance, try to get a prescription for deprenyl
and DHEA. See if any other listed compounds could also be obtained
via prescription so that your health insurance pays for it. Discuss
the advisability of commencing Indomethacin or other nonsteroidal
antiinflammatory drug therapy.
What you can do without your physician: Everything
except Indomethacin or other prescription nonsteroidal
antiinflammatory drug therapy.
If you are unable to have the eye test done, and don't wish to
involve a physician, everything recommended here has general
anti-aging effects, and can be followed by most elderly persons
who wish to retain their health.
Either in consultation with your physician, or on your
own, order the following products, and begin taking at the
recommended dosages:
1. From Beyond-A-Century:
1-800-777-1324, phone credit card orders accepted.
200.2- Life extension mix, low niacin. If you can't take fairly
large tablets, they do have loose powder which can be mixed with
water.
4 bottles of 315 tablets- $138
8 bottles of 315 tablets- $245
204.0- Selenium complex.
1 or 2 bottles of 200mcg x 100 tablets- $5 each
Optional but recommended:
003.5- Performance Extra- Arginine/OKG 2:1 mix, 250 gram
bottle- $28.75 each
2. From Healing Alternatives Foundation:
Use enclosed photocopy of order form. Must mail-order. Credit
cards or checks accepted.
Coenzyme Q-10 (150)
1 or 2 bottles 30mg x 100 capsules- $19.42 (Calif. residents
$20.95).
DHEA-100
1 or 2 bottles 250mg x 100 capsules- $62.87 (Calif. residents
$67.81).
OR: If you have health insurance and your doctor is willing, get
your doctor to prescribe DHEA as hormone replacement therapy at
his recommended dosage and get from your local pharmacy.
OR: If you would rather use a credit card and place a phone order
for DHEA, try:
Atlanta Buyer's Club
(404) 874-4845
AIDS Buyer's Club, takes phone credit card orders.
DHEA- 250mg x 100- Approx. $60.
3. From Life Extension Foundation:
1-800-841-5433, phone credit card orders accepted.
Melatonin
1 or 2 bottles 10mg x 60 capsules- $24 each
1 or 2 bottles 3mg x 60 capsules- $8 each
Acetyl-L-Carnitine
2 to 4 bottles 500mg x 100 capsules- $68 each
4. From A. Werner & Co.
PO Box 615
11121 Prague 1
Czech Republic
Mail orders only, use included photocopy of order form. Send
airmail. Checks or (recommended) money orders accepted. Could
be up to 45 days for delivery, so order sufficient quantity. Need 2
capsules per day.
Deprenyl-100x5 mg capsules-$95, 400x5 mg capsules-$360
Plus $7 shipping.
OR: If you have health insurance and your doctor is willing, get
your doctor to prescribe Deprenyl/Selegiline/Eldepryl, 10mg per
day, and get from your local pharmacy.
5. From Lifelink
445 Liery Lane
Arroyo Grande, CA 93420
(805)473-1389
Pregnenolone: 30mg x 50- $33, or 30mg x 150- $90, or 30mg
x 500- $270, prescription not required.
Plus $4 shipping.
6. From Local Drug Store:
1 bottle enteric-coated aspirin, 325 to 400 mg tablets- Approx.
$6
1 bottle Ibuprofin- Approx. $6
7. From Local Meat Market
Fresh, healthy animal's brains. Begin consuming a small amount
daily or weekly.
Note: All of the above compounds should be refrigerated prior to
use, with the exception of Deprenyl, which should be stored at
room-temperature.
Alzheimer's Disease- Treatment Resources
1. Melatonin- Cost/Day: $0.13 to $0.26. Dosage: One to
three 3 mg capsules or one 10 mg capsule 1/2 hour before sleep,
plus an. additional 3 mg capsule if you wake up with at least 4
hours to go. Source: Life Extension Foundation (1-800-841-
5433), Vitamin Research Products, or Beyond-A-Century.
2. Life Extension Mix- Cost/Day: $1.09 to $0.88
(depending on whether 1,4, or 8 bottles of 315 tablets are bought
at once). Dosage: 3 tablets with each meal (9 per day). Source:
Beyond-A-Century.
Life Extension Mix (LEF) contains the following components which
are specifically called for in my Alzheimer's Treatment Strategy:
Numerous generalized antioxidant and immune system boosting
compounds (vitamins C, E, etc.)
Vitamin B-6: 200 mg
Magnesium (in chloride, aspartate, and succinate forms): 1 gram
Selenium (in sodium selenate and methionine complex): 100 mcg
Contains 50 antioxidant ingredients based on latest scientific and
medical research. Example: Vitamin E was shown in a very large
study to be associated with a 37% reduction in risk of coronary
disease in men and a 41% reduction for women. Formula updated
regularly. One of the best high doseage multivitamins on the
market. This formula is not like a typical multivitamin that you
can get at a drug store, in two important ways: 1. The
sophistication of the formula, and 2. The total amounts. L.E. Mix
contains far more of each component than a typical multivitamin.
Example: to have the anti-arteriosclerotic effect of vitamin E
mentioned above, you need to take at least 100 i.u. (International
Units- a measure of bioactivity) of vitamin E per day. A typical
mulitvitamin has perhaps 37 i.u. L.E. Mix has 600 i.u. of vitamin
E.
Current formula of Life Extension Mix- 9 tablets, capsules or
powder in three divided doses with meals:
Vegetable Complex
Beta-Carotene (ROCHE)- 25,000 i.u.
Xanthophyll complex- 7500 i.u.
Lycopene complex- 10,000 i.u.
Broccoli concentrate- 500 mg
Cabbage concentrate- 500 mg
Vitamin A- 5000 i.u.
B Complex
B1 (Thiamin HCL)- 250 mg
B2 (Riboflavin)- 50 mg
B3 (Niacin 75 mg, Niacinamide 100 mg)- 175 mg
B5 (Calcium pantothenate)- 750 mg
B6 (pyridoxine HCL)- 200 mg
B12 (ion exchange resin)- 100 mcg
PABA- 50 mg
Folate Triglutamate- 800 mcg
Biotin- 200 mcg
Ascorbate Complex
Vitamin C (from Calcium, Magnesium, and niacinamide
ascorbates)- 2500 mg
Ascorbyl palmitate- 500 mg
Acerola juice powder- 300 mg
Tocopherol Complex
Vitamin E (D, L- alpha tocopherol acetate)- 300 i.u.
Vitamin E (D- alpha tocopherol succinate)- 300 i.u.
Amino Acid Complex
L-taurine- 500 mg
N-acetyl-cysteine- 200 mg
L-glutathione- 15 mg
Mineral Complex
Magnesium chloride- 800 mg
Magnesium aspartate- 100 mg
Magnesium succinate- 100 mg
Potassium aspartate- 50 mg
Potassium chloride- 49 mg
Calcium citrate- 500 mg
Calcium stearate- 250 mg
Vitamin D- 200 i.u.
Selenium (sodium selenate)- 50 mcg
Selenium (seleno-methionine Nutr 21)- 50 mcg
Optizinc (tm)- 20 mg
Zinc succinate- 15 mg
Chromate (tm) (GTF chromium niacin bound)- 50 mcg
Chromium picolinate- 50 mcg
Plus Cholinergic and Flavinoid Complexes.
I will assume that the patient is taking this formulation in
recommending doses for the following supplememental compounds.
3. Enteric Coated Aspirin- Cost/day: pennies. Dosage: 1
325mg tablet/day with breakfast. Source: Any drugstore.
Low-dosage aspirin has a dramatic effect on lowering heart
disease. In a study of 22,071 physicians over a 60 month period,
those doctors over 50 years of age taking aspirin had a 44%
reduction in heart attacks. In people with pre-existing heart
disease, aspirin reduced the risk by 47%. Those people with heart
disease that took both aspirin and beta carotene had NO heart
attacks. It also has an effect on cancer apparently by reducing
"platelet-aggregability", or the tendency of cells to attach to other
cells. This is how it prevents heart disease (arteriosclerosis), and
how it also inhibits cancer's "metastasizing", or spreading,
because the cancer cell which floats free must anchor itself
somewhere to begin growing again. Aspirin should be used
cautiously if at all by persons with diabetic retinopathy or poorly
controlled high blood pressure; i.e., those at risk of bleeding-type
disorders.
4. Ibuprofin- Cost/day: pennies. Dosage: 1 tablet/day with
dinner. Source: drug store.
Ibuprofin is an anti-inflammatory drug. People who use ibuprofin
chronically (every day) tend to get Alzheimer's Disease at lower
rates than those who don't.
5. Deprenyl or Eldepryl- Cost/day: $1.80 to $4.80.
Dosage: 10 mg/day. One 5 mg tablet with breakfast, one with
lunch. Source: local pharmacy with prescription (100 x 5mg-
$220) or, much cheaper, without prescription, A. Werner & Co.
(100 x 5mg-$95, 400 x 5mg-$360)
6. DHEA- Cost/day: $0.68 to $2.00. Dosage:
approximately 100-250 mg/day. Source: Most (not all) local
compounding pharmacies($2 for a 100 mg capsule), or Lifelink
(25mg x 180- $40, 195mg x 50- $40, 195mg x 150- $108,
195mg x 500- $340), or, cheapest, Healing Alternatives
Foundation (250mg x 100- $67.81) or Atlanta Buyer's Club
(250mg x 100- approx $60)
7. Selenium complex- Cost/day: pennies. Dose- Two
tablets/day. Source: Beyond-A-Century (200mcg x 100- $5)
8. Acetyl-L-Carnitine- Cost/day: $2.72. Dose- Four 500
mg capsules/day. Two with breakfast, and one with lunch and
dinner. Source: Life Extension Foundation.
9. Pregnenolone- Cost/day: $0.60. Dose- 10 to 100 mg;
start with 30mg. Source: Lifelink.
10. Coenzyme Q10- Cost/day: $0.75 to $0.56. Dose- Four
30 mg capsules/day. Two with breakfast, one with lunch and
dinner. Source: Beyond-A-Century, or, cheapest, Healing
Alternatives Foundation.
11. Magnesium- Cost/day: $0.10 to $1.50. Dose- None, if
taking Life Extension Mix. Otherwise, two tablets magnesium
chloride or one tablet magnesium oxide with each meal. Source:
drugstore.
12. Vitamin B-6. Cost/day: pennies. Dose- None, if taking
Life Extension Mix. Otherwise, 250mg/day. Source: Drugstore or
mail-order vitamin supply.
13. Nonsteroidal Anti-Inflammatory Drug- Ex.-
Indomethacin. Cost/day: unknown. Dose Depends on compound. For
Indomethacin, 100-150 mg/day. Source: Local pharmacy, doctor
prescribed.
14. Fruits & Vegetables In Your Diet
A large study, published April 14, 1994, tested whether high-
dose beta carotene and/or a small dose of vitamin E taken for five
years by men who had smoked for at least 30 years would reduce
lung cancer. It did not. Carcinogenesis may take longer than 5
years; if so, the vitamin intake was started too late. Beta carotene
has been shown in other studies to prevent impairment of the
immune system by UV light and inhibit mouth and cervical cancer.
In another study, beta carotene reduced the risk of heart attacks in
people with preexisting heart disease by 41%. People with heart
disease that took both aspirin and beta carotene had NO heart
attacks.
The evidence supports taking some beta carotene, and Life
Extension Mix contains this compound. The amounts of vitamin E
used in the study were not enough to have any effects, based on
amounts used in previous studies, so the study has no relevance on
vitamin E's effectiveness or lack thereof. Bottom line, the
substances in fruits and vegetables which prevent cancer have not
yet been completely identified. It may also be that diets high in
fruits & vegetables are also low in fat, which may be a
contributing factor for cancer reduction.
Therefore, good judgement dictates that in addition to strategic
supplements, one should try to eat as many fruits & vegetables as
possible.
OPTIONAL BUT RECOMMENDED:
15. Growth Hormone Releaser-Cost/Day: $.48.
Performance Powder Extra (Arginine/Ornithine alpha-keto
glutamate (OKG)) 2:1 mix, 300 gram package, cat. no. 003.5,
$28.75 for 300 grams). Dosage: Men-2 level tablespoons.
Women-1 level tablespoon. Source: Beyond-A-Century.
As you age, your body's production of growth hormone declines.
Certain amino-acid formulations can stimulate growth hormone
release if taken at the proper time and on an empty stomach. The
idea is to mimic the natural release of growth hormone by a young
person. GH is normally released in reaction to two events:
maximum effort exercise (not just jogging, but the 100 yard
dash, for example), and sleep. Take on an empty stomach just
before going to bed (stomach acids associated with foods, especially
sugar, destroy the amino acids). Start with a low dosage and work
your way up. Benefits for both men and women include more rapid
healing, a leaner, more muscular body, and significantly increased
immune response (ability to fight off disease in all it's forms-
from colds to cancer). When taken before sleep, it increases REM
sleep and may produce a sense of well-being. It should not be taken
by someone who has existing cancer. Arginine has recently been
associated with nitric oxide metabolism in the human body. Nitric
oxide appears to be very important for many basic processes,
including blood pressure. Arginine lowers blood pressure,
perhaps because it is a precursor of NO. Arginine is being added to
some intraveinous solutions given surgery patients after surgery
in an attempt to speed healing time.
Resources
Beyond-A-Century
PO Box 713
Greenville, ME 04441
1-800-777-1324
Products offered- most. Free catalog.
Life Extension Mix: Bottle of 315 tablets (35 days worth)-
$30.62 if 8 bottles bought.
Selenium: 100 x 200 mcg selenium complex-$5
Plus $4.50 shipping.
Life Extension Foundation
PO Box 229120
Hollywood, FL 33022-9120
1-800-841-5433
Melatonin: 60 x 3mg: $8, 60 x 10mg: $24
Acetyl-L-Carnitine: 100 x 500mg: $68
Vitamin Research Products
3579 Hwy 50 East
Carson City, NV 89701
(702) 884-1300 & (800) 877-2447 fax-(800) 877-3292
Products offered-most. A research and vitamin formulation sales
company similar to LEF Outstanding free research
newsletter/catalog. Appear to be a conscientious company with
integrity.
Lifelink
445 Liery Lane
Arroyo Grande, CA 93420
(805)473-1389
DHEA-25mg x 180: $40, 195mg x 50: $40, 195mg x 150:
$108, 195mg x 500: $340, prescription not required.
Pregnenolone: 10mg x 90: $20, 30mg x 50: $33, 30mg x 150:
$90, 30mg x 500: $270, prescription not required.
Plus $5 shipping.
Atlanta Buyer's Club
(404) 874-4845
DHEA- 250mg x 100: approx $60, phone credit card orders
taken.
Healing Alternative Foundation
1748 Market Street, Suite 205
San Francisco, CA 94102
(415)626-2316
Free catalog. AIDS buyers club: must join ($1 first time you
order)
DHEA: 100 x 250mg capsules: $62.87 ($67.81 for Calif.
residents)
Coenzyme Q-10: 150 x 30mg: $19.42 ($20.95 for Calif.
residents)
Plus $6 shipping.
A. Werner & Co.
PO Box 615
11121 Prague 1
Czech Republic
Deprenyl-100x5 mg capsules-$95, 400x5 mg capsules-$360
Plus $7 shipping.
Eye Test for Alzheimer's Disease: Procedure
1) Prepare a dilute solution of tropicamide (0.01%).
2) Have the patient sit in a semidarkened room for 2 or 3 minutes.
Measure the resting pupil diameter for 1 minute. Record the average
value on the data sheet. Then administer one drop of the dilute solution
of tropicamide to one eye. Note the time. Begin timing from this point.
3) Examine the eye for pupil diameter for 30 seconds at the following
times after drop administration and record the average value of pupil
diameter on the data sheet.
Times: 2, 8, 15, 22, 29, 41, and 51 min after drop administration.
4) Perform the calculations indicated on the data sheet to convert raw
pupil diameter measurements to percentage changes from the baseline,
or initial measurement.
5) Plot the percentage changes at the measurement times on the
included graph. Compare the profile with the already plotted profiles of
Alzheimer's patients and healthy controls. Which profile more closely
matches the patients profile?
6) If the profile does not indicate Alzheimer's Disease, then consider
the possibility of non-Alzheimer's dementia, such as Korsakoff's
syndrome, multi-infarct demetia, and dementia with an extrapyramidal
syndrome, and get a doctor's advice on diagnosing and treating the
problem. If the profile more closely matches the AD patient's profile,
then proceed with the course of treatment indicated herein, in
consultation with a physician.
