On 28 Jan 1995, Barani wrote:
> I am looking forward to any information towards structural aspects
> or biochemical activity changes of Glyceraldehyde-3(?)-phosphate-
> dehydrogenase or its derivative enzymes that are involved in muscular
> activities in the heart. Has there been any work on any conformational
> changes or loss of activity of this enzyme in heart-patients? I
> strongly presume that there is.
I am just curious as to why you strongly presume GAPDH loss of
function/reduced function for this glycolysis enzyme? Loss of function
of this enzyme would effectively stop glycolysis and both the aerobic and
anaerobic metabolism...they wouldn't just have a heart problem, they
would be dead.
