IUBio

Melatonin-dose for anti-aging

Kevin Goldstein keving at primenet.com
Sat Dec 2 14:37:09 EST 1995


In article <49o18g$rf5 at maureen.teleport.com> jor at teleport.com (Jo Robinson) writes:
>From: jor at teleport.com (Jo Robinson)
>Subject: Re: Melatonin-dose for anti-aging
>Date: 1 Dec 1995 22:57:20 GMT

>Kevin Goldstein (keving at primenet.com) wrote:
>: In article <49gh7j$i48 at maureen.teleport.com> jor at teleport.com (Jo Robinson)
>writes:

>: * snip *

>: >        If you want to continue to experiment with melatonin, I suggest
>: >that you switch brands (in case the #2 explanation applies) and take
>: >a much smaller dose, perhaps 500 micrograms --- 0.5 milligrams.  I have
>: >a good friend who took a 3 mg. dose of KAL brand melatonin and was
>: >awake all night long.  A very bizarre experience.  She switched to
>: >another brand (Life Extension) and dropped the dose down to 1 mg.
>: >She slept like a log and has had no trouble ever since.
>: *snip*
>: >|       Jo Robinson                 |            jor at teleport.com            

>: A question on dosages, Jo. How much are you feeding your rats (mice?) in your 
>: experiement?

>        ** Mice.  They get 1 mg of melatonin per liter of water.  I take
>the melatonin water away in the daytime so they only have the hormone at
>night.
>/l.  
>         And do you know what that amounts to in mg/kg?

>        The melatonin-treated mice weigh, on average, 37 grams when
>last weighed.  The control mice -- 33.3 grams.  If you've visited my
>home page recently, you can see the difference in size at a gland.
>         Also, do you know 
>: what the doses were in some of the published studies that showed life 
>: extension properties for mice? (Again in mg/kg, since I don't know how much 
>: those critters drink in a day.)
>        I surely do.  In the Maestroni/ Pierpaoli experiments, the mice
>were given 10 micrograms per ml.  In the Oaknin-Bendahan study, the rats
>were given 4 mg/liter.   

>: Well, OK, that was three questions.
>        That's all?

>        Jo

>To see the mice, go to http://www.teleport.com/~jor

>--
>+-----------------------------------+-----------------------------------------+
>|       Jo Robinson                 |            jor at teleport.com             |
>|      (503)284-4676                |     2826 NE 18th Portland, OR 97212     | 
>+-----------------------------------+------------------------------------y-----+

I'm still not clear on how much total melatonin they get: am I to assume that 
they drink a liter of water a day? (!!!) Without knowing how much they drink 
in a night, I can't calculate their dosage in mg/kg.

-Kevin Goldstein 




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