jtieber at pobox.com (John Tieber) wrote:
>>>From the most recent (January 1996) issue of Life Extension Magazine
(page 16):
>>³Scientists who¹ve conducted melatonin research have emphasized in
several
>new books that healthy people who don¹t suffer from insomnia _may_ only
>need 500 mcg [1/2 mg] of melatonin per night for optimal antiaging
>benefits.²
>>Later reference to _The Melatonin Miracle_ suggests that the scientists
>referred to are Walter Pierpaoli, MD, PhD; and William Regelson, MD.
>>This is the first mention I¹ve seen that 1/2 mg per night might be
optimal
>for anti-aging. Per this, Life Extension Foundation now offers a 500
mcg
>size (6 month+ supply:$14).
>>I don¹t have trouble sleeping, and would rather spend about $25 per
year
>for my 99.9% purity melatonin than what I¹m spending now.
>>Can anyone contradict the claim that 500 mcg per night is optimal for
>anti-aging purposes? If not, I guess I¹ll have to buy the book,
hopefully
>using some of the money I will then save by reducing my melatonin
>purchases.
Experiments with melatonin and immune response appear to be dose
dependent up to around 10 mg. Since one of the fundamental aging clocks
is the decline of the immune system a higher dose would seem prudent
until lifespan vs dose experiments have been completed. I think the 1/2
mg dose is the knee in the curve for the antioxidantproperty of melatonin.