Kevin Goldstein (keving at primenet.com) wrote:
: In article <49gh7j$i48 at maureen.teleport.com> jor at teleport.com (Jo Robinson) writes:
: * snip *
: > If you want to continue to experiment with melatonin, I suggest
: >that you switch brands (in case the #2 explanation applies) and take
: >a much smaller dose, perhaps 500 micrograms --- 0.5 milligrams. I have
: >a good friend who took a 3 mg. dose of KAL brand melatonin and was
: >awake all night long. A very bizarre experience. She switched to
: >another brand (Life Extension) and dropped the dose down to 1 mg.
: >She slept like a log and has had no trouble ever since.
: *snip*
: >| Jo Robinson | jor at teleport.com
: A question on dosages, Jo. How much are you feeding your rats (mice?) in your
: experiement?
** Mice. They get 1 mg of melatonin per liter of water. I take
the melatonin water away in the daytime so they only have the hormone at
night.
/l.
And do you know what that amounts to in mg/kg?
The melatonin-treated mice weigh, on average, 37 grams when
last weighed. The control mice -- 33.3 grams. If you've visited my
home page recently, you can see the difference in size at a gland.
Also, do you know
: what the doses were in some of the published studies that showed life
: extension properties for mice? (Again in mg/kg, since I don't know how much
: those critters drink in a day.)
I surely do. In the Maestroni/ Pierpaoli experiments, the mice
were given 10 micrograms per ml. In the Oaknin-Bendahan study, the rats
were given 4 mg/liter.
: Well, OK, that was three questions.
That's all?
Jo
To see the mice, go to http://www.teleport.com/~jor
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| Jo Robinson | jor at teleport.com |
| (503)284-4676 | 2826 NE 18th Portland, OR 97212 |
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