Hans Selye and others, paraphrased, suggested that ageing is the decreased
range of response to stress.
I have an approach for producing a physiologically valid Non-Hayflick form of
ageing in fibroblasts in tissue culture. I have standard tissue culture
facilities and both high and low passage human fibroblasts in culture.
I am looking for stimulus-response pairs with which to challenge my
fibroblasts and see if they do display a decreased response in absence of
increased passage number.
Any suggestions??
Please send suggestions to me at kruged at essex.hsc.colorado.edu
