RATTAN at kemi.aau.dk wrote:
: Here is the news of the second anti-ageing discovery.
: Plant hormone KINETIN delays the onset of many cellular and biochemical
: characteristics associated with cellular ageing of cultured human cells.
: Most importantly, these effects are achieved without interfering with the
: maximum proliferative capacity. No additonal cell divisions are induced.
: This is unlike all other anti-ageing things reported for cell cultures
: for example, FGF, PDGF, ginseng, or the latest I reported last week,
: carnosine. All those things induce additional cell divisions which can
: be potentially harmful in terms of making cells move on a path to
: immortalization (here meaning cancer.)
I can think of a situation where the cell division rate is high but
because the gene repair mechanism is also extremely effective as to
result in less carcinogenesis than a converse situation wherein cellular
damage and malfunctioning of gene repair causes low cell division rate
but high carcinogenesis
: Kinetin is N6-furfunyadenine, a modified base that can get incorporated
: in tRNA. It is a synthetic cytokinin. Its nearest natural relative is
: zeatin, but in our experiments Kinetin is the most effective.
: A small free-base, modified a little, having such dramatic effects!!!!
: Various other modifications do not have similar effects, or may be
: very small effects. Also, it has to be free-base and not the nucleoside
: or neucleotide. Apparantly, in plants it does not matter, but in human
: cells it can be a difference of life and death.
Not surprisingly, many what would be considered by-products of plant
metabolism (eg. alkaloids) or waste, turns out to have wonderous
therapeutic effects in animals such as man.
: Natural sources of kinetin related cytokinins are: very high levels
: in coconut water/milk; all germinating seeds and growing tips etc.
Now, this is interesting. Germinating seeds and growing tips presumably
have a high cell division rate, so there must be some other compound(s)
that promote cellular division and yet works in conjunction with these
kinetin related cytokinins. Their high concentration in the germinating
phase may suggest their protective effect against errors in DNA
transcription (and/or RNA) during the cell proliferation stage. Therefore:
(a) Study the effect of kinetin by depletion or enrichment during various
phases of (1) plant and (2) animal cell growth as well as various phases
of the entire plant or animal
: Potential usages as nutrional supplement, anti-oxidative compounds,
: and rejuvenator.
: The paper: Kinetin delays the onset of ageing characteristics in human
: fibroblasts, by SIS Rattan & BFC Clark is in Biochemical Biophysical
: Research Communications, vol 201, pages not sure, 1994.
As far as the financial aspects of this research, let me say that I have
been interested in aging research since age of about 11. However, my
colleagues and I have researched the stock market and are now able to
forecast prices very accurately. See if some medical foundations are
interested in sponsoring your research in return for us providing them
extremely valuable investment forecasts (whereby 50 -100% annual return
is quite normal).
: So much for the good week end news.
Certainly very interesting. Keep up the good work and do post here often.
Sample forecasts follow:
(these were made prior to the opening of the U.S. financial markets on
the evening of June 23, 1994. As you can see, we expected the U.S. stock
market to drop the next day, today, which did happen.)
Subject: Advance Price Forecasts on S&P 100 Stocks (6/23/94).
Summary: Stock Price Forecasting is NOT a Dismal Science
Distribution: world.
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MARKETSCOPE(tm) PRICE FORECASTS ON MAJOR U.S. COMMON STOCKS
***********************************************************
Stock |Company name sorted by |Closing |<%Percent Change>
ticker|its stock ticker symbol|price on| 1-3 2-6 3-9
symbol|in ascending order |06/23/94| Wks Wks Wks
***********************************************************
AA Aluminum Co. of America 74.750 -2 -2 -3
AEP American Electric Power 28.125 -1 -1 1
AGC American General 28.500 1 6 10
AIG American Int'l Group 92.500 -2 -2 -2
AIT Ameritech 41.125 -2 -3 -5
AMP AMP Inc. 67.000 0 -1 -1
AN Amoco 59.000 -2 -1 -1
ARC Atlantic Richfield 101.875 -1 -1 -1
AVP Avon Products 58.500 -1 -1 -1
AXP American Express 26.750 -3 -6 -7
BA Boeing Company 47.875 -2 -3 -3
BAC BankAmerica Corp. 46.625 -3 -4 -4
BAX Baxter International Inc. 25.500 -3 -3 -3
BC Brunswick Corp. 23.625 1 1 -1
BCC Boise Cascade 23.625 -1 -1 -3
BDK Black & Decker Corp. 17.750 1 2 3
BEL Bell Atlantic 55.375 1 1 2
BHI Baker Hughes 21.625 -2 -3 -5
BMY Bristol-Myers Squibb 54.750 -1 -2 -2
BNI Burlington Northern 54.250 0 0 1
BS Bethlehem Steel 19.375 -5 -5 -6
CCB Capital Cities/ABC 73.375 -15 -17 -8
CCI Citicorp 39.125 -4 -4 -5
CEN Ceridian Corp. 24.875 -1 -1 -1
CGP Coastal Corp. 28.000 -1 1 1
CHA Champion International 33.000 -1 -2 -3
CI CIGNA Corp. 71.000 -1 -2 -4
CL Colgate-Palmolive 53.000 6 -4 -5
CSC Computer Sciences Corp. 42.250 0 0 1
CWE Commonwealth Edison 23.250 1 4 4
DAL Delta Air Lines 45.875 -1 -1 -1
DD Du Pont (E.I.) 59.750 0 -1 -1
DEC Digital Equipment 20.375 2 2 2
DIS Walt Disney Co. 42.625 -3 -3 -4
DOW Dow Chemical 67.000 -2 -3 -3
EK Eastman Kodak 47.500 1 0 -1
ETR Entergy Corp. 24.875 -1 0 4
F Ford Motor 57.375 -4 -5 -5
FDX Federal Express 76.000 -1 -1 -1
FLR Fluor Corp. 51.500 -3 -4 -5
FNB First Chicago Corp. 48.375 -3 -3 -5
GD General Dynamics 42.125 -3 -3 -3
GE General Electric 46.250 -1 -1 7
GM General Motors 50.750 -5 -7 -9
GWF Great Western Financial 18.875 4 11 12
HAL Halliburton Co. 34.750 -2 -1 1
HM Homestake Mining 19.750 -2 -5 -4
HNZ Heinz (H.J.) 33.250 0 0 1
HON Honeywell 31.375 -1 0 1
HRS Harris Corp. 45.750 -5 -5 -5
HWP Hewlett-Packard 76.375 -3 -5 -5
I First Interstate Bancorp 75.500 1 -1 -2
IBM International Bus. Machin 60.875 -3 -3 -3
IFF International Flav/Flag 40.000 -1 -1 -2
IMA IMCERA Group Inc. 8.625 -1 -1 -3
INTC Intel Corp. 58.375 0 0 1
IP International Paper 69.000 -2 -2 -2
ITT ITT Corp. 82.500 -2 -3 -3
JNJ Johnson & Johnson 43.250 1 0 0
KM K Mart 15.875 -2 0 0
KO Coca Cola Co. 40.500 -1 -2 -2
LIT Litton Inds. 33.875 3 6 7
LTD Limited, The 17.500 -5 -6 -9
MCD McDonald's Corp. 59.375 1 1 1
MCIC MCI Communications 23.063 -3 -2 -1
MER Merrill Lynch 36.500 -1 -3 -3
MMM Minn. Mining & Mfg. 50.875 1 1 1
MOB Mobil Corp. 83.875 -1 -1 -1
MRK Merck & Co. 30.500 1 1 0
MTC Monsanto Company 77.500 0 -1 -1
NSC Norfolk Southern Corp. 63.500 -3 -3 -3
NSM National Semiconductor 17.500 -10 -11 -11
NT Northern Telecom 28.750 -8 -9 -11
OXY Occidental Petroleum 19.750 -6 0 -1
PCI Paramount Comm. Inc. 48.000 2 2 2
PEP PepsiCo Inc. 31.125 -7 -12 -13
PRD Polaroid Corp. 32.625 -2 -3 -3
PRI Promus Inc. 29.500 -2 -1 -7
RAL Ralston-Ralston Purina Gp 35.875 0 0 1
ROK Rockwell International 38.000 -1 -1 -1
RTN Raytheon Co. 64.875 1 1 2
S Sears, Roebuck & Co. 46.125 -5 -7 -7
SKY Skyline Corp. 19.375 0 0 -1
SLB Schlumberger Ltd. 60.125 -3 -1 0
SO Southern Co. 19.000 -2 -3 -3
T American Tel. & Tel. 55.250 -2 -3 -3
TAN Tandy Corp. 35.875 -1 -2 -3
TDY Teledyne Inc. 17.125 -1 -1 -1
TEK Tektronix Inc. 30.000 4 4 5
TOY Toy R Us 34.125 -1 -1 1
TXN Texas Instruments 74.125 -5 -6 -6
UAL UAL Corp. 125.125 0 3 4
UIS Unisys Corp. 8.875 -23 -34 -31
UPJ Upjohn Co. 30.875 -1 3 4
UTX United Technologies 65.125 -2 -2 -2
WMB Williams Cos. 28.375 -3 -4 -5
WMT Wal-Mart Stores 24.250 -2 -2 -1
WY Weyerhaeuser Corp. 40.125 -1 0 1
XON Exxon Corp. 58.125 -3 -3 -4
XRX Xerox Corp. 98.125 -3 -3 -3
***********************************************************
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Copyright(C) 1994 BY R.M.C. Phone:(408) 773-8715 (voice).
***********************************************************
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We plan to eventually cover ALL major stocks exchanges in
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Best wishes to your continued success in advancing the knowledge of human
aging process.
