In article <3daf91$88r at mserv1.dl.ac.uk>, Rob Baer <KC10%NEMOMUS.bitnet at ACADEMIC.
NEMOSTATE.EDU> writes:
>First, with regard to aging of wild rats:
> I agree that there is no way to obtain an exact age of wild
> species because of individual variablity. I will mention,
> however, a correlate that I have not seen mentioned by others
> and that is cross-linking in the extracellular matrix. A paper,
> discussing this in human's is :
> Sell, DR, and Monnier, VM. Structure elucidation of a Senescence
> cross-link from human extracellular matrix. J. Biol. Chem. 266:
> 21597-21602, 1990.
> This process also occurs over the life-time
> of the primitive least shrew (Orin Mock, Ph.D., Personal
> Communication). I don't know for sure, but presume it also
> occurs in more advancd rodents like the rat.
>>Second regading nutrition and aging:
> Several contributors have asserted recently that eating well
> is associated with an increased life span. There is a wealth
> of experimental evidence to suggest exactly the opposite.
> That is, caloric restriction has been shown to promote longevity
> in experimental animals. A place to start reading about this
> might be:
> YU, BP, How diet influences the aging process of the rat. Proc.
> Soc. Exp. Biol. Med. 205: 97-105,1994.
> Clearly, starvation hastens death; but so too does overeating
> hasten death.
>> I'm headed home to dinner now!! Oh well.
>>I have no idea where I got this but rats that were placed on a eating
schedule of one day on and one day off had a longer life span than
control and there life span was equal to the starvation group.
I tried it many years ago, but each time I was on the diet a friend
would have a party and I am a social animal, so ...
By the way exercise had no effect.
The stavation even for one day is a bad idea because it might rain
and you can go into hyperthermia and die!
If total exposure to oxygen was the largest variable on aging shouldn't
people with easy no exercise lives live longer?
Ron Blue
