The evidence linking mtDNA deletions and aging is accumulating rapidly.
Netters should check out the following references.
Zhang et al (1992) FEBS 297: 34-38
Torii et al (1992) Am J Respir Cell Mol Biol 6:543-549
Cortopassi $ Arnheim (1990) NAR 18(23): 6927-6933
Miquel (1991) Arch Gerontol Geriatr 12: 99-117
Linnane et al (1992) Mutation Res 275: 195-208
Linnane et al (1992) In Adenine Nucleotides in Cellular Energy Transfer
and Signal Transduction, S Papa, A Azzi and JM Tager (eds) Birkhauser
Verlag, Basel/Switzerland, pp 137-149. This last also contains
information on mtDNA deletions in rats with aging and uses an interesting
cell model lacking mtDNA.
Leprat et al (1990) in Mechanisms of Ageing and Development 52: 149-167
have described a technique for monitoring cell ageing and mitochondrial
function using fluorescent probes.
I hope we can keep this discussion going, as the mtDNA theory of aging has
great explanatory potential. In addition, it opens the way to rational
approaches to treating age-related disorders using redox therapy (eg
Coenzyme Q10). One could even speculate on doing mitochondrial transfers
or perfusions to combat ege!
Jim Cummins
Murdoch University
Western Australia
