There have been several messages pointing to the notion that
deletions and mutations in mitochondrial DNA significantly
contribute to either cell or animal ageing. The idea is very attractive,
and there is some interesting, but very indirect evidence for this notion.
But, can anyone direct us to specific data (references) in which AGEING rather tthan disease is correlated with mitochondrial DNA deletions. I have studied thearticle in Science last year, to which Jim Cummings referred, but there is
I think, no direct evidence for this connection with ageing. The relationship
of mit. DNA changes with human diseases, especially muscle, is sound. is there
any evidence for such a connection with ageing, say of the heart; again, I
emphasise, not just with cardiomyopathy which is rather rare. Any bits of direct evidence would be most worthwhile to examine.
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Sydney SHALL,
Laboratory of Cell and Molecular Biology,
Biology Building,
University of Sussex,
Brighton,
East Sussex BN1 9QG,
ENGLAND.
Telephone: +44.273.67.83.03
FAX: +44.273.67.83.33
E-Mail:
Janet: BAFA1 at uk.ac.sussex.central
Elsewhere: BAFA1 at central.sussex.ac.uk
EARN/BITNET: BAFA1%sussex.central at ukacrl
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